๏ปฟ

ื”ืคื•ืจื˜ืœ ื”ื™ืฉืจืืœื™ ืœื—ืงืœืื•ืช ื˜ื‘ืข ื•ืกื‘ื™ื‘ื”

ื—ื“ืฉื•ืช ื—ืงืœืื•ืช, ื˜ื‘ืข, ืกื‘ื™ื‘ื” ื•ื”ื”ืชื™ื™ืฉื‘ื•ืช ื”ื›ืคืจื™ืช โ€ข ืžื“ื•ืจ ื”ื—ื“ืฉื•ืช


ืฉื™ื˜ื” ื—ื“ืฉื” ืขืฉื•ื™ื” ืœืขื–ื•ืจ ืœืกื•ื‘ืœื™ื ืžืฉื™ื‘ื•ืฉ ื‘ืฉืขื•ืŸ ื”ื‘ื™ื•ืœื•ื’ื™


ืžื“ืขื ื™ ืžื›ื•ืŸ ื•ื™ื™ืฆืžืŸ ืœืžื“ืข, ื’ื™ืœื• ื›ื™ ื—ืฉื™ืคื” ืœื—ืžืฆืŸ ื‘ืจืžื•ืช ืžืฉืชื ื•ืช ื’ื•ืจืžืช ืœืกื ื›ืจื•ืŸ ื”ืฉืขื•ื ื™ื ื”ื‘ื™ื•ืœื•ื’ื™ื™ื. ื”ืฉื™ื˜ื” ืขืฉื•ื™ื” ืœื”ืฆื™ืข ืคืชืจื•ืŸ ืœืื ืฉื™ื ื”ืกื•ื‘ืœื™ื ืžื’'ื˜ ืœื’ ื•ื›ืŸ ืžื”ืคืจืขื•ืช ื ื•ืกืคื•ืช ื”ื ื•ื‘ืขื•ืช ืžืฉื™ื‘ื•ืฉ ื‘ืคืขื™ืœื•ืชื• ืฉืœ ื”ืฉืขื•ืŸ ื”ื‘ื™ื•ืœื•ื’ื™

ืžืขืจื›ืช ื”ืคื•ืจื˜ืœ ืœื—ืงืœืื•ืช ื˜ื‘ืข ื•ืกื‘ื™ื‘ื”  29-10-2016



ย ืคืชืจื•ืŸ ืœืกื•ื‘ืœื™ื ืžื’'ื˜-ืœื’, ืฆื™ืœื•ื: ืžืชืŸ ืงื™ื“ืจ

ืื ืืชื ื ื•ื”ื’ื™ื ืœื˜ื•ืก ื‘ืชื“ื™ืจื•ืช ื’ื‘ื•ื”ื”, ืืชื ื‘ื•ื•ื“ืื™ ื™ื•ื“ืขื™ื ืžื” ืขืœื™ื›ื ืœืขืฉื•ืช "ื‘ืžืงืจื” ืฉืœ ื™ืจื™ื“ื” ืคืชืื•ืžื™ืช ื‘ืœื—ืฅ ื”ืื•ื•ื™ืจ ื‘ืชื ื”ื ื•ืกืขื™ื". ืžื” ืฉืื™ื ื›ื ื™ื•ื“ืขื™ื ื”ื•ื ืฉื”ืคื—ืชื•ืช ืžื“ื•ื“ื•ืช ื‘ืœื—ืฅ ื”ืื•ื•ื™ืจ ื‘ืชื ื”ื ื•ืกืขื™ื โ€“ ืื• ืœื™ืชืจ ื“ื™ื•ืง, ื”ืคื—ืชื•ืช ืžืชื•ื ื•ืช ื•ืงืฆืจื•ืช-ื˜ื•ื•ื— ื‘ืจืžื•ืช ื”ื—ืžืฆืŸ โ€“ ืขืฉื•ื™ื•ืช ืœื”ืงืœ ื‘ื™ื•ื ืžืŸ ื”ื™ืžื™ื ืขืœ ืชื•ืคืขืช ื”ื’'ื˜ ืœื’ ื‘ืงืจื‘ ื ื•ืกืขื™ื ื•ืœืกื™ื™ืข ืœื”ื ืœืฉื•ื‘ ืœืฉื’ืจืช ื™ื•ืžื ื‘ืžื”ื™ืจื•ืช.

ยป ืจื•ืฆื™ื ืœืงื‘ืœ ืขื“ื›ื•ื ื™ื ื ื•ืกืคื™ื? ื”ืฆื˜ืจืคื• ืืœื™ื ื• ืœืคื™ื™ืกื‘ื•ืง

ืžืจื‘ื™ืช ื‘ืขืœื™ ื”ื—ื™ื™ื, ืœืจื‘ื•ืช ื‘ื ื™ ืื“ื, ืžืกื•ื’ืœื™ื ืœืžื“ื•ื“ ื–ืžืŸ ื‘ืืžืฆืขื•ืช ืฉืขื•ืŸ ื‘ื™ื•ืœื•ื’ื™ ืคื ื™ืžื™. ืืš ื›ืืฉืจ ืื ืฉื™ื ื˜ืกื™ื ืœื™ืขื“ื™ื ืจื—ื•ืงื™ื ื”ืžืชืงื™ื™ืžื™ื ื‘ืื–ื•ืจ ื–ืžืŸ ื—ื“ืฉ, ื”ื ื—ื•ื•ื™ื ื—ื•ืกืจ ื”ืชืืžื” ื‘ื™ืŸ "ื”ืฉืขื•ืŸ ื”ื‘ื™ื•ืœื•ื’ื™" ืฉื‘ื’ื•ืคื ืœื‘ื™ืŸ ื”ืฉืขื•ืŸ ื”ื—ื™ืฆื•ื ื™ ืœื”ื. ื”ืชื•ืฆืื” ื”ื™ื ื”ืคืจืขื” ื‘ืฉืขื•ืŸ ื”ื‘ื™ื•ืœื•ื’ื™ โ€“ ืื•, ื‘ืžื™ืœื™ื ืื—ืจื•ืช โ€“ "ื™ืขืคืช" (ื’'ื˜-ืœื’).

ืฉื™ื˜ื” ื—ื“ืฉื” ืฉืคื™ืชื—ื• ืžื“ืขื ื™ ืžื›ื•ืŸ ื•ื™ืฆืžืŸ ืœืžื“ืข, ืขืฉื•ื™ื” ืœื”ืฆื™ืข ืคืชืจื•ืŸ ืœืื ืฉื™ื ื”ืกื•ื‘ืœื™ื ืžื™ืขืคืช ื•ื›ืŸ ืžื”ืคืจืขื•ืช ื ื•ืกืคื•ืช ื”ื ื•ื‘ืขื•ืช ืžืฉื™ื‘ื•ืฉ ื‘ืคืขื™ืœื•ืชื• ืฉืœ ื”ืฉืขื•ืŸ ื”ื‘ื™ื•ืœื•ื’ื™. ื”ืฉื™ื˜ื”, ืฉืžื‘ื•ืกืกืช ืขืœ ื—ืฉื™ืคื” ืœืื•ื•ื™ืจ ื“ืœื™ืœ ื‘ื—ืžืฆืŸ, ื”ื•ื›ื—ื” ื›ื™ืขื™ืœื” ื‘ื ื™ืกื•ื™ ืขืœ ืขื›ื‘ืจื™ื ื•ืชื•ืืจื” ื‘ืื—ืจื•ื ื” ื‘ื›ืชื‘ ื”ืขืช ื”ืžื“ืขื™ Cell Metabolism.

"ืจืื™ื ื• ื›ื™ ื‘ืขื›ื‘ืจื™ื ืฉื ื—ืฉืคื• ืœืฉื™ื ื•ื™ื™ื ื‘ืจืžื•ืช ื”ื—ืžืฆืŸ โ€“ ื”ื™ืขืคืช ืงื•ืฆืจื” ืžืฉืžืขื•ืชื™ืช", ืื•ืžืจ ื“"ืจ ื’ื“ ืืฉืจ ืžื”ืžื—ืœืงื” ืœืžื“ืขื™ื ื‘ื™ื•ืžื•ืœืงื•ืœืจื™ื™ื, ืืฉืจ ืขื•ืžื“ ื‘ืจืืฉ ืงื‘ื•ืฆืช ื”ืžื—ืงืจ. ืืช ื”ืžื—ืงืจ ื”ื•ื‘ื™ืœื• ื“"ืจ ื™ืขืจื™ืช ืื“ืžื•ื‘ื™ืฅ' ืชืžื ื•ื”ื—ื•ืงืจ ื”ื‘ืชืจ-ื“ื•ืงื˜ื•ืจื™ืืœื™ ื“"ืจ ื‘ื ื’'ืžื™ืŸ ืœืื“ื•ืง. ื›ืŸ ื”ื™ื• ืฉื•ืชืคื™ื ื‘ืžื—ืงืจ ื“"ืจ ืžืจื™ื ื” ื’ื•ืœื™ืง ืžืžืขื‘ื“ืชื• ืฉืœ ื“"ืจ ืืฉืจ ื•ื“"ืจ ืžืจื˜ืŸ ืงื•ื ืจืก, ืžืื•ื ื™ื‘ืจืกื™ื˜ืช ื‘ืจื™ืกื˜ื•ืœ, ื‘ืจื™ื˜ื ื™ื”.

ื”ืžื“ืขื ื™ื ื‘ื™ืงืฉื• ืœื”ืชื—ืงื•ืช ืื—ืจ ื”ืื•ืช ื”ื‘ื™ื•ืœื•ื’ื™ ืฉืžืืคืฉืจ ืืช ืกื ื›ืจื•ืŸ ื›ืœืœ ื”ืฉืขื•ื ื™ื ื‘ื’ื•ืฃ. "ื”ืฉืขื•ืŸ ื”ื‘ื™ื•ืœื•ื’ื™ ืžื•ืจื›ื‘ ืžืžื™ืœื™ื•ื ื™ ืฉืขื•ื ื™ื ื”ืžืฆื•ื™ื™ื ื‘ื›ืœ ืื™ื‘ืจ ื•ืชื ื‘ื’ื•ืฃ", ืžืกื‘ื™ืจื” ื“"ืจ ืื“ืžื•ื‘ื™ืฅ' ืชืžื. "ืจืฆื™ื ื• ืœื”ื‘ื™ืŸ ืžื”ื• ื”ื“ื‘ืจ ื”ืžืืคืฉืจ ืืช ื”ืชื™ืื•ื ื‘ื™ื ื™ื”ื, ื›ืš ืฉื™ืชืงืชืงื• ื‘ื”ืจืžื•ื ื™ื”". ื—ื™ืœื•ืฃ ื—ื•ืžืจื™ื ื•ื˜ืžืคืจื˜ื•ืจื” โ€“ ื›ืš ื™ื“ื•ืข ืœืžื“ืขื ื™ื โ€“ ืงืฉื•ืจื™ื ืฉื ื™ื”ื ืœืฆืจื™ื›ืช ื—ืžืฆืŸ ื•ื™ื“ื•ืขื™ื ื›ื’ื•ืจืžื™ื ื“ื•ืžื™ื ื ื˜ื™ื™ื ื‘ืกื ื›ืจื•ืŸ ื”ืฉืขื•ื ื™ื ื‘ื’ื•ืฃ. ืœืื•ืจ ื–ืืช, ื”ื ื™ืฆืื• ืœื‘ื“ื•ืง ืื ื’ื ื—ืžืฆืŸ ืขืฉื•ื™ ืœื”ื•ื•ืช ืื•ืช ืžืกื ื›ืจืŸ ืœืฉืขื•ื ื™ื ื‘ื’ื•ืฃ.


ื“"ืจ ื’ื“ ืืฉืจ ื•ื“"ืจ ื™ืขืจื™ืช ืื“ืžื•ื‘ื™ืฅ' ืชืžื, ืฆื™ืœื•ื: ื‘ืื“ื™ื‘ื•ืช ืžื›ื•ืŸ ื•ื™ืฆืžืŸ ืœืžื“ืข

"ื™ืฉื ืŸ ืฉืœื•ืฉ ื“ืจื™ืฉื•ืช ืžืื•ืช ื›ื–ื”", ืžืกื‘ื™ืจ ื“"ืจ ืืฉืจ. "ืจืืฉื™ืช, ืชืื™ ื”ื’ื•ืฃ ืฆืจื™ื›ื™ื ืœื”ื›ื™ืจ ืื•ืชื•; ืฉื ื™ืช, ื”ื•ื ืฆืจื™ืš ืœื”ื™ื•ืช ื‘ืขืœ ืžืงืฆื‘ ื™ื•ืžื™ โ€“ ื›ืœื•ืžืจ, ืขืœื™ื• ืœื”ื’ื™ืข ืœืจืžืช ืฉื™ื ืžื“ื™ 24 ืฉืขื•ืช ื•ื›ืš ืœื”ืขื‘ื™ืจ 'ืžืกืจ' ืœื’ื‘ื™ ื”ืฉืขื”; ื•ืฉืœื™ืฉื™ืช, ื”ื•ื ื—ื™ื™ื‘ ืœื”ืฉืคื™ืข ืขืœ ื›ืœ ืชืื™ ื”ื’ื•ืฃ ื•ืœื’ืจื•ื ืœื”ื ืœื”ืฆื™ื’ ืืช ืื•ืชื” ื”ืฉืขื”".

ื—ืžืฆืŸ ืžื–ื•ื”ื” ืขืœ ื™ื“ื™ ืžืจื‘ื™ืช ืชืื™ ื”ื’ื•ืฃ, ื•ืœื›ืŸ ืขื•ื ื” ื‘ื•ื•ื“ืื•ืช ืขืœ ื”ื“ืจื™ืฉื” ื”ืจืืฉื•ื ื”. ืืš ืžื” ืœื’ื‘ื™ ื™ืชืจ ื”ื“ืจื™ืฉื•ืช? ื‘ื ื™ืกื•ื™ ืฉืขืจื›ื• ื‘ืขื›ื‘ืจื™ื, ืจืื• ื”ืžื“ืขื ื™ื ืฉืœืฆืจื™ื›ืช ื—ืžืฆืŸ ื•ืœื ื•ื›ื—ื•ืชื• ื‘ื“ื ื™ืฉ ืžืงืฆื‘ ื™ื•ืžื™. "ื”ื™ื” ืœื ื• ื—ืฉื•ื‘ ืœื”ื‘ื™ืŸ ืื ืฉื™ื ื•ื™ื™ื ื™ื•ืžื™ื™ื ืืœื” ืžื•ืจื’ืฉื™ื ื’ื ืขืœ-ื™ื“ื™ ื”ืจืงืžื•ืช ื‘ื—ื™ื”", ืื•ืžืจ ื“"ืจ ืœืื“ื•ื•ื™ืงืก. ืœืฆื•ืจืš ื›ืš, ื”ืกืชื™ื™ืขื• ื”ืžื“ืขื ื™ื ื‘ื˜ื›ื ื•ืœื•ื’ื™ื” ื”ืงื™ื™ืžืช ื‘ืžืขื‘ื“ืชื• ืฉืœ ื“"ืจ ืงื•ื ืจืก โ€“ ืืœืงื˜ืจื•ื“ื” ื”ืžื•ืฉืชืœืช ื‘ื›ื™ืœื™ื” ืฉืœ ื—ื•ืœื“ื”, ื•ืžื ื˜ืจืช ื‘ื” ืืช ืจืžื•ืช ื”ื—ืžืฆืŸ, ื‘ืขื•ื“ ื”ื—ื™ื” ื ืขื” ื‘ื—ื•ืคืฉื™ื•ืช ื‘ื›ืœื•ื‘. "ืจืื™ื ื• ืฉืจืžื•ืช ื”ื—ืžืฆืŸ ื‘ื›ื™ืœื™ื” ื ืขื•ืช ื‘ืžืงืฆื‘ ื™ื•ืžื™ โ€“ ื›ืœื•ืžืจ, ื”ืŸ ืžื’ื™ืขื•ืช ืžื“ื™ ื™ืžืžื” ืœื ืงื•ื“ืช ืฉื™ื", ืื•ืžืจ ื“"ืจ ืืฉืจ.

ืœื‘ืกื•ืฃ, ื‘ื—ื ื• ื”ืžื“ืขื ื™ื ืื ืฉื™ื ื•ื™ ื™ื•ืžื™ ื‘ืจืžื•ืช ื”ื—ืžืฆืŸ ืžืกื•ื’ืœ "ืœื•ืžืจ" ืœืฉืขื•ื ื™ื ืžื” ื”ืฉืขื” โ€“ ืžื” ืฉื™ืขื ื” ืขืœ ื”ื“ืจื™ืฉื” ื”ืฉืœื™ืฉื™ืช. ืœืฆื•ืจืš ื›ืš, ื”ื ื—ืฉืคื• ืชืจื‘ื™ืช ืจืงืžื” ืฉืฉืขื•ื ื™ื” ืื™ื ื ืžืกื•ื ื›ืจื ื™ื ืœืจืžื•ืช ืžืฉืชื ื•ืช ืฉืœ ื—ืžืฆืŸ ื‘ืื•ืคืŸ ื”ืžื—ืงื” ืืช ื”ืžืฆื‘ ื‘ื—ื™ื”. ื›ืคื™ ืฉืฆื™ืคื•, ื”ื ื’ื™ืœื• ืฉื—ืฉื™ืคื” ื–ื• ื’ืจืžื” ืœืฉืขื•ื ื™ ื”ืชืื™ื ืœื”ืกืชื ื›ืจืŸ ื‘ืขื•ื“ ืฉื”ืฉืขื•ื ื™ื ื‘ืงื‘ื•ืฆืช ื”ื‘ื™ืงื•ืจืช, ืืฉืจ ืฉื”ื• ื‘ืจืžืช ื—ืžืฆืŸ ืงื‘ื•ืขื”, ืœื ืกื•ื ื›ืจื ื•.

"ื”ืจืื™ื ื• ืฉื—ืžืฆืŸ ืžืกื•ื’ืœ ืœื’ืจื•ื ืœืกื ื›ืจื•ืŸ ื”ืฉืขื•ื ื™ื โ€“ ื”ืฉืคืขื” ืฉืžืขื•ืœื ืœื ื ื—ืงืจื” ืื• ืชื•ืืจื” ื‘ื”ืงืฉืจ ืœืฉืขื•ื ื™ื ื‘ื™ื•ืœื•ื’ื™ื™ื", ืื•ืžืจ ื“"ืจ ืืฉืจ. ื‘ื”ืžืฉืš ืœื›ืš, ื’ื™ืœื• ื”ืžื“ืขื ื™ื ืฉื”ืชื”ืœื™ืš ืชืœื•ื™ ื‘ื—ืœื‘ื•ืŸ ื”ืžืขื•ื“ื“ ื‘ื™ื˜ื•ื™ ื’ื ื™ื ื•ื‘ืขืฆืžื• ืžื•ืฉืคืข ืžื—ืžืฆืŸ ื•ื ืงืจื HIF1.

ื”ืฉืœื‘ ื”ืื—ืจื•ืŸ ื›ืœืœ ืืช ื™ื™ืฉื•ื ื”ืื•ืช "ื‘ืฉื˜ื—". ืœืฆื•ืจืš ื›ืš, ื”ืžื“ืขื ื™ื ืฉื™ื ื• ื‘ืื•ืคืŸ ืžืœืื›ื•ืชื™ ืืช ืฉืขื•ื ื™ื”ื ื”ื‘ื™ื•ืœื•ื’ื™ื™ื ืฉืœ ื”ืขื›ื‘ืจื™ื, ื‘ืžื˜ืจื” ืœื™ืฆื•ืจ ืืฆืœื ื™ืขืคืช. "ืฉื™ื ื™ื ื• ืืช ืžืฉื˜ืจ ื”ืื•ืจ ื•ื”ื—ื•ืฉืš ืฉืœ ื”ืขื›ื‘ืจื™ื, ืžื” ืฉื’ืจื ืœื›ืš ืฉืงืคืฆื• ืฉืฉ ืฉืขื•ืช ืงื“ื™ืžื” ื‘ื–ืžืŸ. ืžืฆื‘ ื–ื” ืžื“ืžื” ื˜ื™ืกื” ืžื™ืฉืจืืœ ืœืื—ืช ืžืžื“ื™ื ื•ืช ื”ืžื–ืจื— ื”ืจื—ื•ืง", ืžืกื‘ื™ืจื” ื“"ืจ ืื“ืžื•ื‘ื™ืฅ' ืชืžื.

ื‘ืกืžื•ืš ืœื™ืขืคืช ืฉื—ื•ื•, ืงื‘ื•ืฆื” ืื—ืช ืฉืœ ืขื›ื‘ืจื™ื ื ื—ืฉืคื” ืœืจืžื•ืช ื—ืžืฆืŸ ื ืžื•ื›ื•ืช ืœืžืฉืš ื›ืžื” ืฉืขื•ืช. ืงื‘ื•ืฆื” ืื—ืจืช โ€“ ืฉืฉื™ืžืฉื” ื›ืงื‘ื•ืฆืช ื‘ื™ืงื•ืจืช โ€“ ื ื—ืฉืคื” ืœืจืžื” ืงื‘ื•ืขื” ืฉืœ ื—ืžืฆืŸ. ื”ืชื•ืฆืื”: ืืฆืœ ื”ืขื›ื‘ืจื™ื ื‘ืงื‘ื•ืฆื” ื”ืจืืฉื•ื ื” ื”ื™ืขืคืช ืงื•ืฆืจื” ืžืฉืžืขื•ืชื™ืช ื‘ื”ืฉื•ื•ืื” ืœืงื‘ื•ืฆืช ื”ื‘ื™ืงื•ืจืช.

"ื”ืจืื™ื ื• ืฉืฉื™ื ื•ื™ื™ื ื‘ืจืžื•ืช ื”ื—ืžืฆืŸ ืžืกื•ื’ืœื™ื ืœืกื ื›ืจืŸ ืฉืขื•ื ื™ื ื‘ื™ื•ืœื•ื’ื™ื™ื ื‘ืขื›ื‘ืจื™ื ื•ืœืฉืคืจ ืžืฉืžืขื•ืชื™ืช ืืช ื–ืžืŸ ื”ื”ืชืื•ืฉืฉื•ืช ืžื™ืขืคืช", ืื•ืžืจ ื“"ืจ ืืฉืจ. "ื”ืื ื ื•ื›ืœ ืœืจืื•ืช ืืช ื”ื”ืฉืคืขื” ื”ื–ื• ื’ื ื‘ื‘ื ื™ ืื“ื? ืฉืืœื” ื–ื• ืขื“ื™ื™ืŸ ืคืชื•ื—ื”".

ืขื•ื“ ื”ื•ื ืžื•ืกื™ืฃ: "ืžื“ื•ื‘ืจ ื‘ืชื•ืฆืื•ืช ืžืจื’ืฉื•ืช ื”ืŸ ื‘ืคืŸ ื”ืžื“ืขื™ ื•ื”ืŸ ื‘ื›ืœ ื”ื ื•ื’ืข ืœืคื•ื˜ื ืฆื™ืืœ ื”ื™ื™ืฉื•ืžื™ ื”ื˜ืžื•ืŸ ื‘ื’ื™ืœื•ื™. ื›ืขืช, ืœืžืฉืœ, ืื ื• ื‘ื•ื“ืงื™ื ืื ืื•ื•ื™ืจ ืขืฉื™ืจ ื‘ื—ืžืฆืŸ ื™ื›ื•ืœ ืœื”ื•ื‘ื™ืœ ื’ื ื”ื•ื ืœืฉื™ืคื•ืจ ื‘ื™ืขืคืช. ืื ื”ืฉื™ื˜ื” ืชืชื‘ืจืจ ื›ื™ืขื™ืœื” ื‘ื‘ื ื™ ืื“ื, ื ื•ื›ืœ ืœื—ืฉื•ื‘ ืขืœ ืคืชืจื•ื ื•ืช ืคืฉื•ื˜ื™ื ืœื™ื™ืฉื•ื ืฉืœื”; ืœืžืฉืœ โ€“ ืฉื™ืžื•ืฉ ื‘ืžืกื›ืช ื—ืžืฆืŸ ื‘ืžื˜ื•ืก".












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